Dr. Sam is an adult endocrinologist who specializes in the diagnosis and treatment of polycystic ovary syndrome (PCOS). She also has a clinical interest in other reproductive disorders leading to menstrual irregularity in women, type 2 diabetes and related metabolic disorders.
Dr. Sam’s research focuses on the metabolic abnormalities associated with PCOS such as the high risk for development of type 2 diabetes, lipid disorders and obesity. In particular she examines how abnormalities in fat tissue such as inflammation lead to development of insulin resistance in PCOS. She has received prestigious research grants and has published her findings in a number of scientific journals, including Proceedings of the National Academy of Sciences, Diabetes, Diabetes Care, and the Journal of Clinical Endocrinology and Metabolism.
She serves as a manuscript reviewer for scientific journals such as Clinical Endocrinology, Obesity and Fertility and Sterility and is on the editorial board for the Journal of Clinical Endocrinology and Metabolism. Dr. Sam is a teacher and mentor to medical students, residents and endocrinology fellows.
- Polycystic ovary syndrome
- Reproductive disorders
- Type 2 diabetes
- Thyroid disorders
University of Illinois at Chicago
Internship, Residency, and Fellowship
Northwestern University, Feinberg School of Medicine
Year Started Practice
- American Diabetes Association
- The Endocrine Society
- Huang ZH, Manickam B, Ryvkin V, Zhou Xiaohong Joe, Fantuzzi G, Mazzone T, and Sam S. 2013. PCOS is associated with increased CD11c expression and crown Like Structures in adipose tissue and increased central abdominal fat depots independent of obesity. J Clin Endocrinol and Metab 98: E17-24. http://jcem.endojournals.org/98/4797-4802
- Mokhlesi B, Scoccia B, Mazzone T, Sam S. 2012. Risk of Obstructive Sleep Apnea in Obese and Nonobese Women with Polycystic Ovary Syndrome and Healthy Reproductively Normal Women. Fertil Steril 97: 786-791. http://www.fertstert.org/97/786-791
- Sidhwani, S, Scoccia, B, Sunghay, S, Stephens-Archer, CN, Mazzone, T & Sam S. 2011. PCOS is associated with atherogenic changes in lipoprotein particle number and size independent of body weight. Clin Endocrinol 75:76-82. NIHSID: NIHMS273639
- Sam S, Legro RS, Dunaif A. 2006. Evidence for heritable changes in metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome. Proc Natl Acad Sci U S A 103:7030-7035. http://www.pnas.org/103/7030-7035
- Sam S, Haffner S, Davidson MH, D’Agostino RB, Feinstein S, Kondos G, Perez A, Mazzone T. 2009. Association between abdominal visceral and subcutaneous adipose tissue and markers of inflammation in type 2 diabetes. Diabetes Care 32:932-937. http://care.diabetesjournals.org/32/932-937