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Manami Hara, Ph.D.

The overall goal of Dr. Hara’s research program is to identify and characterize the cells that define the lineage that gives rise to the pancreatic beta cell. She has generated a series of lines of transgenic mice expressing green fluorescent protein (GFP) and DsRed1 under the control of a series of transcription factors that characterize different cell types in the beta cell lineage. She is characterizing the pattern of gene expression in these genetically-tagged cells using expression profiling with Affymetrix GeneChips and custom arrays. These studies may lead to the identification of the stem cell which gives rise to the pancreatic beta cell and open up new avenues for preventing and treating diabetes.